When Cancer Starves an Immune Cell, Quantum Sensors May Hear the Chemistry

Cell chemistry changes under pressure

In a solid tumor, an engineered immune cell may carry the right receptor and still lose function as nutrients disappear and suppressive metabolites accumulate. A proposed four-year project at Heriot-Watt University aims to watch that chemistry in real time. The planned platform combines single-electron sensors, optical spectroscopy, and microfluidics to follow radical activity across many cells. Its medical premise is specific: the local chemical environment may help explain why cellular immunotherapies that have changed treatment for several blood cancers remain much harder to use against solid tumors.

A diamond spin can report a local signal

The program has an experimental starting point. In a 2024 Carbon paper, Claudia Reyes-San-Martin and colleagues, including fellowship leader Aldona Mzyk, used diamond-based quantum sensing to detect free-radical signals in migrating human breast cancer cells with subcellular resolution. They observed radical formation after defined periods of starvation and low-serum migration, then changed NOX2 activity and found that the radical measurement, broader reactive-oxygen readings, and cell migration did not move together. That result makes the sensing method interesting as a mechanistic probe. It does not establish a cancer biomarker or a patient-facing diagnostic.

The next experiment moves to immune-cell failure

Heriot-Watt's December 15, 2025 announcement says the funded work will study how the tumor microenvironment disrupts immune-cell metabolism. The National Cancer Institute describes that suppressive environment as one of several barriers facing CAR T-cell therapy in solid tumors, alongside target selection and tumor variation. The proposed system could give researchers a closer view of when individual cells begin to fail and how differently cells respond under the same conditions. Important questions remain open: whether the signal is stable across instruments, whether thousands-of-cells throughput can preserve nanoscale sensitivity, and whether a radical pattern predicts later immune function. The project is best understood as a laboratory measurement program with a credible route into cancer immunology and a long clinical distance still ahead.